DDIT3
DDIT3(DNA damage-inducible transcript 3)またはCHOP(C/EBP homologous protein)は、DDIT3
構造
[
C/EBPファミリーの
調節 と機能
[CHOPは
上流 の調節 経路
[アミノ酸 枯渇 (GCN2を介 して)[13]- ウイルス
感染 (PKRを介 して)[14] 鉄 の欠乏 (HRIを介 して)[15]小 胞体でのフォールディングしていない、または誤 ってフォールディングしたタンパク質 の蓄積 によるストレス(PERKを介 して)[16]
下流 の経路
[ミトコンドリア依存 的 経路 を介 したアポトーシスの誘導
[CHOPは
TRB3は、
デスレセプター経路 を介 したアポトーシスの誘導
[デスレセプターを
PERK-ATF4-CHOP
その他 の下流 経路 を介 したアポトーシスの誘導
[CHOPは、ERO1
CHOPの
相互 作用
[
DDIT3(CHOP)は
臨床 的 意義
[脂肪 肝 と高 インスリン血 症 における役割
[マウスでは、Chop
GLP1-アンチセンスオリゴヌクレオチドデリバリーシステム[63]によるChop
感染 における役割
[- ブタサーコウイルス2
型 (PCV2)(PERK-eIF2α -ATF4-CHOP-BCL2経路 )[65] - HIV(XBP1-CHOP-カスパーゼ-3/9
経路 )[66][67] 鶏 伝染 性 気管支炎 ウイルス(PERK-eIF2α -ATF4-CHOP経路 またはPKR-eIF2α -ATF4-CHOP経路 )[68]結核 菌 (PERK-eIF2α -ATF4-CHOP経路 )[69][70]- ピロリ
菌 (PERK-eIF2α -ATF4-CHOP経路 またはPKR-eIF2α -ATF4-CHOP経路 )[71] 大腸菌 (CHOP-DR5-カスパーゼ-3/8経路 )[72]志賀 赤痢 菌 (p38-CHOP-DR5経路 )[73]
CHOPは
その他 の疾患 における役割
[CHOPはアポトーシスを
CHOPの
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000175197 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025408 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C”. Molecular and Cellular Biology 11 (2): 1009–16. (February 1991). doi:10.1128/MCB.11.2.1009. PMC 359769. PMID 1990262 .
- ^ a b c “Entrez Gene: DDIT3 DNA-damage-inducible transcript 3”. 2022
年 9月 3日 閲覧 。 - ^ “Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element”. Molecular and Cellular Biology 16 (4): 1479–89. (April 1996). doi:10.1128/MCB.16.4.1479. PMC 231132. PMID 8657121 .
- ^ “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription”. Genes & Development 6 (3): 439–53. (March 1992). doi:10.1101/gad.6.3.439. PMID 1547942.
- ^ “A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure”. Nature Communications 8 (1): 133. (July 2017). Bibcode: 2017NatCo...8..133Y. doi:10.1038/s41467-017-00171-w. PMC 5527107. PMID 28743963 .
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- ^ “Roles of CHOP/GADD153 in endoplasmic reticulum stress”. Cell Death and Differentiation 11 (4): 381–9. (April 2004). doi:10.1038/sj.cdd.4401373. PMID 14685163.
- ^ “ER stress and diseases”. The FEBS Journal 274 (3): 630–58. (February 2007). doi:10.1111/j.1742-4658.2007.05639.x. PMID 17288551.
- ^ “GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis”. The Journal of Pathology 239 (4): 411–25. (August 2016). doi:10.1002/path.4738. PMID 27135434.
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- ^ “The Role of the PERK/eIF2
α /ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress”. Current Molecular Medicine 16 (6): 533–44. (2016). doi:10.2174/1566524016666160523143937. PMC 5008685. PMID 27211800 . - ^ “ER stress-induced cell death mechanisms”. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833 (12): 3460–3470. (December 2013). doi:10.1016/j.bbamcr.2013.06.028. PMC 3834229. PMID 23850759 .
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- ^ “Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway”. Neuroscience 388: 284–296. (September 2018). doi:10.1016/j.neuroscience.2018.07.023. PMID 30036660.
- ^ “ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response”. Molecular and Cellular Biology 20 (18): 6755–67. (September 2000). doi:10.1128/mcb.20.18.6755-6767.2000. PMC 86199. PMID 10958673 .
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- ^ “The unfolded protein response: integrating stress signals through the stress sensor IRE1
α ”. Physiological Reviews 91 (4): 1219–43. (October 2011). doi:10.1152/physrev.00001.2011. hdl:10533/135654. PMID 22013210. - ^ “Transcription Factor C/EBP Homologous Protein in Health and Diseases”. Frontiers in Immunology 8: 1612. (2017). doi:10.3389/fimmu.2017.01612. PMC 5712004. PMID 29230213 .
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- ^ “Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase”. Science 272 (5266): 1347–9. (May 1996). Bibcode: 1996Sci...272.1347W. doi:10.1126/science.272.5266.1347. PMID 8650547.
- ^ “How IRE1 reacts to ER stress”. Cell 132 (1): 24–6. (January 2008). doi:10.1016/j.cell.2007.12.017. PMID 18191217.
- ^ “Attenuation of CHOP-mediated myocardial apoptosis in pressure-overloaded dominant negative p38
α mitogen-activated protein kinase mice”. Cellular Physiology and Biochemistry 27 (5): 487–96. (2011). doi:10.1159/000329970. PMID 21691066. - ^ a b “Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway”. Anti-Cancer Drugs 28 (1): 66–74. (January 2017). doi:10.1097/
CAD .0000000000000431. PMID 27603596. - ^ “UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression”. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300 (1): R92-100. (January 2011). doi:10.1152/ajpregu.00169.2010. PMID 21068199 .
- ^ “The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity”. Archives of Toxicology 88 (6): 1267–80. (June 2014). doi:10.1007/s00204-014-1240-8. hdl:10533/127482. PMID 24748426.
- ^ “CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress”. PLOS ONE 7 (6): e39586. (2012-06-28). Bibcode: 2012PLoSO...739586G. doi:10.1371/journal.pone.0039586. PMC 3386252. PMID 22761832 .
- ^ “Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA”. The Journal of Neuroscience 30 (50): 16938–48. (December 2010). doi:10.1523/JNEUROSCI.1598-10.2010. PMC 6634926. PMID 21159964 .
- ^ “Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element”. Molecular and Cellular Biology 16 (4): 1479–89. (April 1996). doi:10.1128/mcb.16.4.1479. PMC 231132. PMID 8657121 .
- ^ “Cell death induced by endoplasmic reticulum stress”. The FEBS Journal 283 (14): 2640–52. (July 2016). doi:10.1111/febs.13598. PMID 26587781.
- ^ “The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques”. Arteriosclerosis, Thrombosis, and Vascular Biology 30 (10): 1925–32. (October 2010). doi:10.1161/ATVBAHA.110.206094. PMID 20651282.
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- ^ “TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1”. American Journal of Physiology. Renal Physiology 299 (5): F965-72. (November 2010). doi:10.1152/ajprenal.00236.2010. PMC 2980398. PMID 20660016 .
- ^ “Loss of C/EBP-
β LIP drives cisplatin resistance in malignant pleural mesothelioma”. Lung Cancer 120: 34–45. (June 2018). doi:10.1016/j.lungcan.2018.03.022. PMID 29748013. - ^ “HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4”. Cellular Signalling 26 (3): 556–63. (March 2014). doi:10.1016/j.cellsig.2013.11.026. PMID 24308964.
- ^ “TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death”. The EMBO Journal 24 (6): 1243–55. (March 2005). doi:10.1038/sj.emboj.7600596. PMC 556400. PMID 15775988 .
- ^ “TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver”. Science 300 (5625): 1574–7. (June 2003). Bibcode: 2003Sci...300.1574D. doi:10.1126/science.1079817. PMID 12791994.
- ^ “TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells”. Oncology Letters 15 (1): 1343–1349. (January 2018). doi:10.3892/ol.2017.7361. PMC 5769383. PMID 29391905 .
- ^ a b c “DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells”. The Journal of Biological Chemistry 290 (17): 11108–18. (April 2015). doi:10.1074/jbc.M115.645333. PMC 4409269. PMID 25770212 .
- ^ “Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells”. Clinical Cancer Research 22 (16): 4145–57. (August 2016). doi:10.1158/1078-0432.CCR-15-2254. PMID 26983464.
- ^ “Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis”. Science 345 (6192): 98–101. (July 2014). Bibcode: 2014Sci...345...98L. doi:10.1126/science.1254312. PMC 4284148. PMID 24994655 .
- ^ “Apoptosis: a review of programmed cell death”. Toxicologic Pathology 35 (4): 495–516. (June 2007). doi:10.1080/01926230701320337. PMC 2117903. PMID 17562483 .
- ^ “CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum”. Genes & Development 18 (24): 3066–77. (December 2004). doi:10.1101/gad.1250704. PMC 535917. PMID 15601821 .
- ^ a b “Fusion of the EWS and CHOP genes in myxoid liposarcoma”. Oncogene 12 (3): 489–94. (February 1996). PMID 8637704.
- ^ “NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis”. The Journal of Cell Biology 191 (6): 1113–25. (December 2010). doi:10.1083/jcb.201006121. PMC 3002036. PMID 21135141 .
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- ^ a b “GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis”. Journal of Cellular Biochemistry 117 (8): 1813–21. (August 2016). doi:10.1002/jcb.25481. PMC 4909508. PMID 26729625 .
- ^ “Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis”. BMC Cancer 13: 96. (March 2013). doi:10.1186/1471-2407-13-96. PMC 3598994. PMID 23448667 .
- ^ “Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10”. Molecular and Cellular Biology 16 (3): 1157–68. (March 1996). doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660 .
- ^ a b c “CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins”. Molecular and Cellular Biology 19 (11): 7589–99. (November 1999). doi:10.1128/MCB.19.11.7589. PMC 84780. PMID 10523647 .
- ^ “C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform”. FEBS Letters 541 (1–3): 33–9. (April 2003). doi:10.1016/s0014-5793(03)00283-7. PMID 12706815.
- ^ “Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress”. The Journal of Biological Chemistry 271 (24): 14285–9. (June 1996). doi:10.1074/jbc.271.24.14285. PMID 8662954.
- ^ “CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation”. The Journal of Biological Chemistry 278 (42): 40514–20. (October 2003). doi:10.1074/jbc.M306404200. PMID 12876286.
- ^ “Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis”. The Journal of Biological Chemistry 275 (11): 7591–6. (March 2000). doi:10.1074/jbc.275.11.7591. PMID 10713066.
- ^ Song, Benbo; Scheuner, Donalyn; Ron, David; Pennathur, Subramaniam; Kaufman, Randal J. (October 2008). “Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes”. The Journal of Clinical Investigation 118 (10): 3378–3389. doi:10.1172/JCI34587. ISSN 0021-9738. PMC 2528909. PMID 18776938 .
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英語 ). Diabetologia 55 (4): 1167–1178. doi:10.1007/s00125-011-2427-7. ISSN 0012-186X. PMID 22237685 . - ^ a b Yong, Jing; Parekh, Vishal S.; Reilly, Shannon M.; Nayak, Jonamani; Chen, Zhouji; Lebeaupin, Cynthia; Jang, Insook; Zhang, Jiangwei et al. (2021-07-28). “Chop/Ddit3 depletion in
β cells alleviates ER stress and corrects hepatic steatosis in mice”. Science Translational Medicine 13 (604). doi:10.1126/scitranslmed.aba9796. ISSN 1946-6242. PMC 8557800. PMID 34321322 . - ^ WO application 2017192820, Monia, Brett P.; Thazha P. Prakash & Garth A. Kinberger et al., "GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof", published 2017-11-09, assigned to Ionis Pharmaceuticals Inc. and AstraZeneca AB
- ^ Yong, Jing; Johnson, James D.; Arvan, Peter; Han, Jaeseok; Kaufman, Randal J. (August 2021). “Therapeutic opportunities for pancreatic
β -cell ER stress in diabetes mellitus”. Nature Reviews. Endocrinology 17 (8): 455–467. doi:10.1038/s41574-021-00510-4. ISSN 1759-5037. PMC 8765009. PMID 34163039 . - ^ a b “Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells”. Viruses 8 (2): 56. (February 2016). doi:10.3390/v8020056. PMC 4776210. PMID 26907328 .
- ^ “HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction”. Molecular Neurobiology 53 (1): 132–142. (January 2016). doi:10.1007/s12035-014-8991-3. PMC 4787264. PMID 25409632 .
- ^ “HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1
α , JNK and AP-1 pathway”. Scientific Reports 6: 18929. (January 2016). Bibcode: 2016NatSR...618929S. doi:10.1038/srep18929. PMC 4703964. PMID 26740125 . - ^ “Upregulation of CHOP/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway”. Journal of Virology 87 (14): 8124–34. (July 2013). doi:10.1128/JVI.00626-13. PMC 3700216. PMID 23678184 .
- ^ “Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis”. PLOS ONE 6 (12): e28531. (2011). Bibcode: 2011PLoSO...628531L. doi:10.1371/journal.pone.0028531. PMC 3237454. PMID 22194844 .
- ^ “Induction of ER stress in macrophages of tuberculosis granulomas”. PLOS ONE 5 (9): e12772. (September 2010). Bibcode: 2010PLoSO...512772S. doi:10.1371/journal.pone.0012772. PMC 2939897. PMID 20856677 .
- ^ “Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis”. PLOS ONE 8 (12): e82322. (2013). Bibcode: 2013PLoSO...882322A. doi:10.1371/journal.pone.0082322. PMC 3862672. PMID 24349255 .
- ^ “Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells”. Cellular Microbiology 10 (3): 770–80. (March 2008). doi:10.1111/j.1462-5822.2007.01083.x. PMID 18005243.
- ^ “Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells”. Toxins 9 (10): 319. (October 2017). doi:10.3390/toxins9100319. PMC 5666366. PMID 29027919 .
- ^ “Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells”. Endocrinology 148 (7): 3258–70. (July 2007). doi:10.1210/en.2006-1564. PMID 17431003.
- ^ “C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation”. Mucosal Immunology 7 (6): 1452–66. (November 2014). doi:10.1038/mi.2014.34. PMID 24850428.
関連 文献
[- “CCAAT/enhancer-binding proteins: structure, function and regulation”. The Biochemical Journal 365 (Pt 3): 561–75. (August 2002). doi:10.1042/BJ20020508. PMC 1222736. PMID 12006103 .
- “Roles of CHOP/GADD153 in endoplasmic reticulum stress”. Cell Death and Differentiation 11 (4): 381–9. (April 2004). doi:10.1038/sj.cdd.4401373. PMID 14685163.
- “Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)”. Genes, Chromosomes & Cancer 5 (4): 278–85. (November 1992). doi:10.1002/gcc.2870050403. PMID 1283316.
- “Isolation, characterization and chromosomal localization of the human GADD153 gene”. Gene 116 (2): 259–67. (July 1992). doi:10.1016/0378-1119(92)90523-R. PMID 1339368 .
- “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription”. Genes & Development 6 (3): 439–53. (March 1992). doi:10.1101/gad.6.3.439. PMID 1547942.
- “Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2”. Cancer Genetics and Cytogenetics 48 (1): 101–7. (August 1990). doi:10.1016/0165-4608(90)90222-V. PMID 2372777.
- “Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma”. Nature Genetics 4 (2): 175–80. (June 1993). doi:10.1038/ng0693-175. PMID 7503811.
- “Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma”. Nature 363 (6430): 640–4. (June 1993). Bibcode: 1993Natur.363..640C. doi:10.1038/363640a0. PMID 8510758.
- “Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10”. Molecular and Cellular Biology 16 (3): 1157–68. (March 1996). doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660 .
- “Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase”. Science 272 (5266): 1347–9. (May 1996). Bibcode: 1996Sci...272.1347W. doi:10.1126/science.272.5266.1347. PMID 8650547.
- “Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress”. The Journal of Biological Chemistry 271 (24): 14285–9. (June 1996). doi:10.1074/jbc.271.24.14285. PMID 8662954.
- “CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins”. Molecular and Cellular Biology 19 (11): 7589–99. (November 1999). doi:10.1128/MCB.19.11.7589. PMC 84780. PMID 10523647 .
- “Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis”. The Journal of Biological Chemistry 275 (11): 7591–6. (March 2000). doi:10.1074/jbc.275.11.7591. PMID 10713066.
- “Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP”. The Journal of Biological Chemistry 277 (14): 12343–50. (April 2002). doi:10.1074/jbc.M107988200. PMID 11805088.
- “Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells”. Oncogene 21 (14): 2171–80. (March 2002). doi:10.1038/sj.onc.1205279. PMID 11948400.
- “Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis”. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1583 (1): 108–16. (June 2002). doi:10.1016/s1388-1981(02)00190-7. PMID 12069855.
- “Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells”. Oncogene 21 (27): 4289–300. (June 2002). doi:10.1038/sj.onc.1205529. PMID 12082616.
外部 リンク
[- DDIT3 protein, human - MeSH・アメリカ
国立 医学 図書館 ・生命 科学 用語 シソーラス