casein kinase

Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.

Casein kinase 1δでるた-IN-3 (Compound 23a) is an inhibitor of casein kinase 1 delta (CK1δでるた) with a pIC50 of 6.5376 M.

Casein kinase 1δでるた-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δでるた with potential application in Alzheimer's disease research [1].

Casein kinase 1δでるた-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δでるた (CK1δでるた) and can be utilized in the study of neurodegenerative diseases, such as Alzheimer's disease.

Casein kinase 1δでるた-IN-8 is an inhibitor of casein kinase 1δでるた and is used to treat neurodegenerative diseases such as Alzheimer's disease type.

Casein kinase 1δでるた-IN-7 is a Casein kinase 1δでるた inhibitor for neurodegenerative diseases such as Alzheimer's disease.

Casein Kinase inhibitor A51 is an orally active casein kinase 1αあるふぁ (CK1αあるふぁ) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, breast and prostate cancers.

Casein kinase 1δでるた-IN-5 is a potent and selective CK-1δでるた inhibitor (IC50 = 47 nM) that exhibits neuroprotective and anti-inflammatory effects in vitro, with potential applications in neurodegenerative disease research.

Casein kinase 1δでるた-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δでるた with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δでるた-IN-6 can be used to study neurodegenerative diseases.

Casein kinase 1δでるた-IN-10 is an inhibitor of casein kinase 1δでるた (CK1δでるた).

TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

TBB (NSC-231634)(NSC-231634) is a highly selective, ATP GTP-competitive inhibitor of casein kinase-2 (CK2).

DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).

D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).

LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kαあるふぁ, PI3Kδでるた, and PI3Kβべーた (IC50=0.5/0.57/0.97 μみゅーM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μみゅーM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.

CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μみゅーM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).

Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.

Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.

CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM. CK2-IN-4 has potential anticancer ah and anti-inflammatory activity for the study of viral infections and glomerulonephritis diseases.

CK2αあるふぁ-IN-1 is a selective non-ATP-competitive CK2αあるふぁ inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2αあるふぁ-IN-1 exhibits potential anticancer activity and can be used in cancer research.

WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μみゅーM.

XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induct

TAK-715 is a p38 MAPK inhibitor for p38αあるふぁ.

Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1εいぷしろん in isolated enzyme preparations.

AS-252424 is a potent and selective inhibitor of PI3Kγがんま with an IC50 of 33 nM and demonstrates over 10-fold selectivity for PI3Kγがんま versus PI3Kαあるふぁ.

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβべーたR-I.

MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.

CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inflammation diseases.

SR-3029 is a highly potent and specific inhibitor of CK1δでるた CK1εいぷしろん.

CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δでるた, and CK1εいぷしろん, p38σしぐま MAPK, respectively.

Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs).

TA-01 is a potent inhibitor of CK1 and p38 MAPK, with IC50 values of 6.4 nM for CK1εいぷしろん, 6.8 nM for CK1δでるた, and 6.7 nM for p38 MAPK.

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μみゅーM and 80 μみゅーM, respectively[1], and also inhibits PKA (Ki=4.3 μみゅーM), casein kinase II (Ki=5.1 μみゅーM), and myosin light chain kinase (MLCK) (Ki=7.4 μみゅーM).

IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μみゅーM and for Cdk5 is 4.5 mM.

(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.

PF-4800567 is a selective inhibitor of casein kinase 1εいぷしろん (CK1εいぷしろん; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δでるた.

Longdaysin is an inhibitor of CK1αあるふぁ and CK1δでるた (IC50s: 5.6 8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).

NCC007 is a novel CKIαあるふぁ and CKIδでるた dual inhibitors by structural modification of N9 and C2 position of longdaysin.

BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2αあるふぁ (IC50 = 10 μみゅーM).

CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μみゅーM; Ki: 8.5 μみゅーM) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.

PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.

CK2 Inhibitor 2, characterized as a potent, selective, and orally active inhibitor of CK2, demonstrates an impressive IC50 value of 0.66 nM. It exhibits high selectivity towards Clk2 with an IC50 of 32.69 nM in comparison to CK2. Furthermore, CK2 Inhibitor 2 has been shown to possess promising antiproliferative and antitumor activities [1].

CKI-7 free base is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μみゅーM; Ki: 8.5 μみゅーM) and a selective Cdc7 kinase inhibitor, also inhibiting SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM).

LH846 is a selective inhibitor of CK1δでるた with IC50 values of 290 nM for CK1δでるた, 1.3 μみゅーM for CK1εいぷしろん, and 2.5 μみゅーM for CK1αあるふぁ, and exhibits no inhibitory activity at CK2.

IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1δでるた inhibitor (IC50=40 nM for M82FCK1δでるた). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research.