槲 皮 素
檞皮 | |
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IUPAC 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | |
别名 | 栎精 檞黃酮 |
识别 | |
CAS |
117-39-5 ![]() |
PubChem | 5280343 |
ChemSpider | 4444051 |
SMILES |
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InChI |
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InChIKey | REFJWTPEDVJJIY-UHFFFAOYAW |
KEGG | C00389 |
C15H10O7 | |
302.236 g·mol⁻¹ | |
1.799 g/cm3 | |
熔点 | 316 °C |
檞皮
檞皮
檞皮
澳
苷元
[编辑]檞皮
生理 活性
[编辑]对
檞皮
炎症
[编辑]一些实验室的研究表明槲皮素可能具有抗炎特性[14][15],并在
檞皮
一项对老鼠的研究表明,
癌 症
[编辑]实验
代 谢
[编辑]檞皮
药物相互 作用
[编辑]檞皮
《AHFS药物
此外,檞皮
参考 文献
[编辑]- ^
存 档副本 . [2020-07-02]. (原始 内容 存 档于2020-07-25). - ^ Quercetin. Merriam-Webster. [2011-06-30]. (
原始 内容 存 档于2020-09-24). - ^ Quercitin (biochemistry). Encyclopedia Brittanica. [2011-06-30]. (
原始 内容 存 档于2014-03-18). - ^ Christiane Fischer, Volker Speth, Sonja Fleig-Eberenz, and Gunther Neuhaus. lnduction of Zygotic Polyembryos in Wheat: lnfluence of Auxin Polar Transport (PDF). Plant Cell. 1999-10, 9 (10): 1767–1780. PMC 157020
. PMID 12237347. doi:10.1105/tpc.9.10.1767.
- ^ USDA Database for the Flavonoid Content of Selected Foods 互联网档
案 馆的 存 檔,存 档日期 2012-07-16. - ^ Crystal Smith, Kevin A. Lombard, Ellen B. Peffley, Weixin Liu. Genetic Analysis of Quercetin in Onion (Allium cepa L.) Lady Raider (PDF). The Texas Journal of Agriculture and Natural Resource (Agriculture Consortium of Texas). 2003, 16: 24–8. (
原始 内容 (PDF)存 档于2007年 2月 25日 ). - ^ Sari H. Häkkinen; et al. Content of the Flavonols Quercetin, Myricetin, and Kaempferol in 25 Edible Berries. Journal of Agricultural and Food Chemistry. 1999, 47 (6): 2274–9. PMID 10794622. doi:10.1021/jf9811065.
- ^ A. E. Mitchell, Y. J. Hong, E. Koh, D. M. Barrett, D. E. Bryant, R. F. Denison and S. Kaffka. Ten-Year Comparison of the Influence of Organic and Conventional Crop Management Practices on the Content of Flavonoids in Tomatoes. Journal of Agricultural and Food Chemistry. 2007, 55 (15): 6154–9. PMID 17590007. doi:10.1021/jf070344.
- ^ Honey Research Unit
- ^ honey fingerprinting. [2011-06-30]. (
原始 内容 存 档于2016-03-04). - ^ Mullen W; et al. Bioavailability of [2-(14)C]quercetin-4'-glucoside in rats. J Agric Food Chem. December 2008, 2456 (24): 12127–37. PMID 19053221. doi:10.1021/jf802754s.
- ^ US FDA, Center for Food Safety and Nutrition, Qualified Health Claims Subject to Enforcement Discretion, April 2007
存 档副本 . [2011-06-30]. (原始 内容 存 档于2009-05-14). - ^ Hickson, LaTonya J.; Langhi Prata, Larissa G.P.; Bobart, Shane A.; Evans, Tamara K.; Giorgadze, Nino; Hashmi, Shahrukh K.; Herrmann, Sandra M.; Jensen, Michael D.; Jia, Qingyi; Jordan, Kyra L.; Kellogg, Todd A.; Khosla, Sundeep; Koerber, Daniel M.; Lagnado, Anthony B.; Lawson, Donna K.; LeBrasseur, Nathan K.; Lerman, Lilach O.; McDonald, Kathleen M.; McKenzie, Travis J.; Passos, João F.; Pignolo, Robert J.; Pirtskhalava, Tamar; Saadiq, Ishran M.; Schaefer, Kalli K.; Textor, Stephen C.; Victorelli, Stella G.; Volkman, Tammie L.; Xue, Ailing; Wentworth, Mark A.; Wissler Gerdes, Erin O.; Zhu, Yi; Tchkonia, Tamara; Kirkland, James L. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine. September 2019, 47: 446–456. PMC 6796530
. PMID 31542391. doi:10.1016/j.ebiom.2019.08.069.
- ^ 14.0 14.1 Laura K. Stewart, Jeff L. Soileau, David Ribnicky, Zhong Q. Wang, Ilya Raskin, Alexander Poulev, Martin Majewski, William T. Cefalu, and Thomas W. Gettys. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism. 2008, 57.
- ^ 15.0 15.1 15.2 J. Mark Davis, E. Angela Murphy, Martin D. Carmichael, and Ben Davis, Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance, Am J Physiol Regul Integr Comp Physiol, 2009, 296
- ^ Phys Ed: Is Quercetin Really a Wonder Sports Supplement? (页面
存 档备份,存 于互联网档案 馆)By Gretchen Reynolds. New York Times, October 7, 2009. Review of the research. - ^ Balabolkin, II; Gordeeva, GF; Fuseva, ED; Dzhunelov, AB; Kalugina, OL; Khamidova, MM. Use of vitamins in allergic illnesses in children. Voprosy meditsinskoi khimii. 1992, 38 (5): 36–40. PMID 1492394.
- ^ Hirano, T; Kawai, M; Arimitsu, J; Ogawa, M; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergology international : official journal of the Japanese Society of Allergology. 2009, 58 (3): 373–82. PMID 19454839. doi:10.2332/allergolint.08-OA-0070.
- ^ Kawai, M; Hirano, T; Arimitsu, J; Higa, S; Kuwahara, Y; Hagihara, K; Shima, Y; Narazaki, M; Ogata, A. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. International archives of allergy and immunology. 2009, 149 (4): 359–68. PMID 19295240. doi:10.1159/000205582.
- ^ Mainardi, T; Kapoor, S; Bielory, L. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. The Journal of allergy and clinical immunology. 2009, 123 (2): 283–94; quiz 295–6. PMID 19203652. doi:10.1016/j.jaci.2008.12.023.
- ^ Papaliodis D, Boucher W, Kempuraj D, Theoharides TC. The flavonoid luteolin inhibits niacin-induced flush. Brit J Pharmacol. 2008, 153 (7): 1382–87. PMC 2437911
. PMID 18223672. doi:10.1038/sj.bjp.0707668.
- ^ Kalogeromitros, D; Makris, M; Chliva, C; Aggelides, X; Kempuraj, D; Theoharides, TC. A quercetin containing supplement reduces niacin-induced flush in humans. International journal of immunopathology and pharmacology. 2008, 21 (3): 509–14. PMID 18831918.
- ^ Verschoyle RD, Steward WP, Gescher AJ. Putative cancer chemopreventive agents of dietary origin-how safe are they?. Nutr Cancer. 2007, 59 (2): 152–62. PMID 18001209. doi:10.1080/01635580701458186 (
不 活 跃 2009-06-26). - ^ Rietjens IM, Boersma MG, van der Woude H, Jeurissen SM, Schutte ME, Alink GM. Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat. Res. July 2005, 574 (1–2): 124–38. PMID 15914212. doi:10.1016/j.mrfmmm.2005.01.028.
- ^ van der Woude H, Alink GM, van Rossum BE; et al. Formation of transient covalent protein and DNA adducts by quercetin in cells with and without oxidative enzyme activity. Chem. Res. Toxicol. December 2005, 18 (12): 1907–16. PMID 16359181. doi:10.1021/tx050201m.
- ^ Guidance for Industry: A Food Labeling Guide XI. Appendix C: Health Claims, 21 CFR 101.76 and 21 CFR 101.78, April 2008. US Department of Health and Human Services, Food and Drug Administration. [2011-06-30]. (
原始 内容 存 档于2013-03-07). - ^ Neuhouser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer. 2004, 50 (1): 1–7. PMID 15572291. doi:10.1207/s15327914nc5001_1.
- ^ Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett. October 2008, 269 (2): 315–25. PMID 18467024. doi:10.1016/j.canlet.2008.03.046.
- ^ Nöthlings U; et al. Flavonols and pancreatic cancer risk. American Journal of Epidemiology. 2007, 166 (8): 924–931. PMID 17690219. doi:10.1093/aje/kwm172.
- ^ Paliwal S; Sundaram, J; Mitragotri, S. Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound. British Journal of Cancer. 2005, 92 (3): 499–502 [2011-06-30]. PMC 2362095
. PMID 15685239. doi:10.1038/sj.bjc.6602364. (
原始 内容 存 档于2017-08-16). - ^ Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009, 296 (4): R1071–7. PMID 19211721. doi:10.1152/ajpregu.90925.2008.
- ^ Clinicaltrials.gov, National Institutes of Health. [2011-06-30]. (
原始 内容 存 档于2020-07-25). - ^ Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 1 November 2007, 137 (11): 2405–11. PMID 17951477.
- ^ Egert S; et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009, 102 (7): 1065–1074. PMID 19402938. doi:10.1017/S0007114509359127.
- ^ Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, Baile CA. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008, 82 (19–20): 1032–9. PMID 18433793. doi:10.1016/j.lfs.2008.03.003.
- ^ Hilliard JJ, Krause HM, Bernstein JI; et al. A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv. Exp. Med. Biol. 1995, 390: 59–69. PMID 8718602.
- ^
存 档副本 . [2011-06-22]. (原始 内容 存 档于2011-07-07). - ^ Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J. Drug interactions of paclitaxel metabolism in human liver microsomes. J Chemother. 2003-06, 15 (3): 266–74. PMID 12868554.
- ^ Bun SS, Giacometti S, Fanciullino R, Ciccolini J, Bun H, Aubert C. Effect of several compounds on biliary excretion of paclitaxel and its metabolites in guinea-pigs. Anticancer Drugs. 2005–07, 16 (6): 675–82. PMID 15930897. doi:10.1097/00001813-200507000-00013.
- ^ Si Dayong, Wang Y, Zhou Y-H, Guo Y, Wang J, Zhou H, Li Z-S, Fawcett JP. Mechanism of CYP2C9 inhibition by flavones and flavonols (PDF). Drug Metabolism and Disposition. March 2009, 37 (3): 629–634. [2011-06-30]. PMID 19074529. doi:10.1124/dmd.108.023416. (
原始 内容 存 档 (PDF)于2008-12-17). - ^ Su-Lan Hsiu; Yu-Chi Hou; Yao-Horng Wang; Chih-Wan Tsao; Sheng-Fang Sue; and Pei-Dawn L. Chao. Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sciences. 6 December 2002, 72 (3): 227–235. PMID 12427482. doi:10.1016/S0024-3205(02)02235-X.
- ^ Judy L. Raucy. Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products. Drug Metabolism and Disposition. 1 May 2003, 31 (3): 533–539. PMID 12695340. doi:10.1124/dmd.31.5.533.
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