E2F1

E2F transcription factor 1
E2F transcription factor 1
	PDB rendering based on 2aze.
有效ゆうこう结构
PDB	直系ちょっけい同どう源みなもと检索：PDBe, RCSB
PDB查询代だい码列表ひょう
	1H24, 1O9K, 2AZE
标识
代だい号ごう	E2F1; E2F-1; RBAP1; RBBP3; RBP3
扩展标识	遗传学がく：189971 鼠ねずみ基もと因いん：101941 同どう源みなもと基はじめ因いん：3828 ChEMBL: 4382 GeneCards: E2F1 Gene
基もと因いん本体ほんたい论描述じゅつ
分子ぶんし功こう能のう	· core promoter binding; · DNA binding; · sequence-specific DNA binding transcription factor activity; · transcription corepressor activity; · protein binding; · transcription factor binding; · sequence-specific DNA binding;
细胞成分せいぶん	· nucleus; · nucleoplasm; · cytoplasm; · Rb-E2F complex;
生物せいぶつ过程	· DNA damage checkpoint; · G1 phase of mitotic cell cycle; · G1/S transition of mitotic cell cycle; · G2 phase of mitotic cell cycle; · negative regulation of transcription from RNA polymerase II promoter; · mitotic cell cycle; · transcription, DNA-dependent; · regulation of transcription, DNA-dependent; · apoptotic process; · spermatogenesis; · cell proliferation; · positive regulation of gene expression; · forebrain development; · negative regulation of transcription, DNA-dependent; · positive regulation of transcription, DNA-dependent; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of fibroblast proliferation; · mRNA stabilization; · cellular response to fatty acid; · cellular response to hypoxia; · negative regulation of transcription involved in G1/S phase of mitotic cell cycle; · regulation of G1/S transition of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA表ひょう达模式しき
	更さら多た表ひょう达数据すえ
直系ちょっけい同どう源みなもと体たい
物もの种	人ひと类
Entrez	1869
Ensembl	ENSG00000101412
UniProt	Q01094
mRNA序列じょれつ	NM_005225
蛋白たんぱく序列じょれつ	NP_005216
基もと因いん位置いち	Chr 20:; 32.26 – 32.27 Mb
PubMed查询	[1]
	查; 论; 编;

转录因子いんしE2F1是ぜ由人よしと类E2F1基もと因いん编码出で的てき蛋白たんぱく质^[1]。

该基因いん编码出で的てき蛋白たんぱく质是E2F转录因子いんし家族かぞく中ちゅう的てき成なり员。E2F家族かぞく在ざい控ひかえ制せい细胞周期しゅうき及抑癌がん基もと因いん功こう能のう上起かみおこし到いた重要じゅうよう作用さよう，也是小しょうDNA致癌病毒びょうどく转化蛋白たんぱく的てき靶点。E2F家族かぞく中ちゅう的てき多た个成员蛋白しろ包含ほうがん许多进化保守ほしゅ的てき结构域いき。这些结构域いき包括ほうかつ：DNA结合域いき、与あずか受分化か调控的てき转录因子いんし蛋白たんぱく（DP）之の间相互そうご作用さよう的てき二聚化结构域、富とみ含酸性せい氨基酸さん的てき转活化か结构域いき以及位い于转活かつ化か结构域いき中ちゅう的てき抑そもそも癌がん蛋白たんぱく关联结构域いき。该蛋白しろ与あずか其他两个成なり员E2F2及E2F3具有ぐゆう额外的てき周期しゅうき蛋白たんぱく结合结构域いき。该蛋白しろ以细胞周期き依よ赖性的てき模も式しき优先与あずか视网膜まく母はは细胞瘤こぶ蛋白たんぱくpRB结合。它可以同时介导细胞增殖ぞうしょく及p53-依よ赖/非ひ依よ赖的细胞凋亡^[2]。

转录

E2F1的てき启动子こ区く有ゆうPAX8转录因子いんし的てき结合序列じょれつ，可か促进E2F1的てき转录^[3]。

相互そうご作用さよう

E2F1与あずか下しも列れつ蛋白たんぱく具有ぐゆう相互そうご作用さよう：NCOA6^[4]、视网膜まく母はは细胞瘤こぶ样蛋白しろ1^[5]、视网膜まく母はは细胞瘤こぶ蛋白たんぱく^[5]^[6]^[7]^[8]^[9]^[10]^[11]、GTF2H1^[12]、SKP2^[13] PURA,^[14]、NPDC1^[15]、Sp2转录因子いんし^[16]、Sp1转录因子いんし^[16]^[17]^[18]、CUL1^[13] ARID3A,^[19]、TOPBP1^[20]^[21]、周期しゅうき蛋白たんぱくA1^[22]、TP53BP1^[8]、周期しゅうき蛋白たんぱくA2^[23]、Sp4转录因子いんし^[16]、Sp3转录因子いんし^[16]、抗こう增殖ぞうしょく蛋白たんぱく^[24]^[25]^[26]^[27]、NDN^[11]^[28]、MDM4^[29] TFDP1^[10]^[19]^[30]^[31]及泛素C^[32]。

另见

参考さんこう文献ぶんけん

^ Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. Structure and partial genomic sequence of the human E2F1 gene. Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9.
^ Entrez Gene: E2F1 E2F transcription factor 1. （原始げんし内容ないよう存そん档于2019-10-16）.
^ Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190.
^ Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation. Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867.
^ ^5.0 ^5.1 Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233 . PMID 8230483.
^ Nicolas, E; Ait-Si-Ali S, Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res. (England). August 2001, 29 (15): 3131–6. PMC 55834 . PMID 11470869. doi:10.1093/nar/29.15.3131.
^ Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J. Biol. Chem. (United States). December 2002, 277 (52): 50860–6. ISSN 0021-9258. PMID 12397079. doi:10.1074/jbc.M203839200.
^ ^8.0 ^8.1 Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P. Inhibition of E2F-mediated transcription by p202. EMBO J. (ENGLAND). October 1996, 15 (20): 5668–78. ISSN 0261-4189. PMC 452311 . PMID 8896460.
^ Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). July 2000, 97 (14): 7738–43. ISSN 0027-8424. PMC 16614 . PMID 10869426. doi:10.1073/pnas.130198397.
^ ^10.0 ^10.1 Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. (UNITED STATES). May 1995, 15 (5): 2536–46. ISSN 0270-7306. PMC 230484 . PMID 7739537.
^ ^11.0 ^11.1 Taniura, H; Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J. Biol. Chem. (UNITED STATES). January 1998, 273 (2): 720–8. ISSN 0021-9258. PMID 9422723. doi:10.1074/jbc.273.2.720.
^ Vandel, L; Kouzarides T. Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. EMBO J. (ENGLAND). August 1999, 18 (15): 4280–91. ISSN 0261-4189. PMC 1171504 . PMID 10428966. doi:10.1093/emboj/18.15.4280.
^ ^13.0 ^13.1 Marti, A; Wirbelauer C, Scheffner M, Krek W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. (ENGLAND). May 1999, 1 (1): 14–9. ISSN 1465-7392. PMID 10559858. doi:10.1038/8984.
^ Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011.
^ Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843.
^ ^16.0 ^16.1 ^16.2 ^16.3 Rotheneder, H; Geymayer S, Haidweger E. Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213.
^ Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153 . PMID 8657142.
^ Karlseder, J; Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152 . PMID 8657141.
^ ^19.0 ^19.1 Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163.
^ Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207 . PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003.
^ Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. The BRCT domain is a phospho-protein binding domain. Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753.
^ Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.
^ Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381 . PMID 7969176.
^ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148.
^ Fusaro, Gina; Dasgupta Piyali, Rastogi Shipra, Joshi Bharat, Chellappan Srikumar. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J. Biol. Chem. (United States). November 2003, 278 (48): 47853–61. ISSN 0021-9258. PMID 14500729. doi:10.1074/jbc.M305171200.
^ Wang, Sheng; Zhang Baohua, Faller Douglas V. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057 . PMID 12065415. doi:10.1093/emboj/cdf302.
^ Wang, S; Nath N, Fusaro G, Chellappan S. Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol. Cell. Biol. (UNITED STATES). November 1999, 19 (11): 7447–60. ISSN 0270-7306. PMC 84738 . PMID 10523633.
^ Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200.
^ Strachan, Gordon D; Jordan-Sciutto Kelly L, Rallapalli Ravikumar, Tuan Rocky S, Hall David J. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J. Cell. Biochem. (United States). February 2003, 88 (3): 557–68. ISSN 0730-2312. PMID 12532331. doi:10.1002/jcb.10318.
^ Sardet, C; Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg R A. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). March 1995, 92 (6): 2403–7. ISSN 0027-8424. PMC 42492 . PMID 7892279. doi:10.1073/pnas.92.6.2403.
^ Helin, K; Wu C L, Fattaey A R, Lees J A, Dynlacht B D, Ngwu C, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. (UNITED STATES). October 1993, 7 (10): 1850–61. ISSN 0890-9369. PMID 8405995. doi:10.1101/gad.7.10.1850.
^ Zhou, Fangfang; Zhang Long, Wang Aijun, Song Bo, Gong Kai, Zhang Lihai, Hu Min, Zhang Xiufang, Zhao Nanming, Gong Yandao. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J. Biol. Chem. (United States). May 2008, 283 (21): 14506–15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200.

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.^{[永久えいきゅう失效しっこう連結れんけつ]}

深入ふかいり阅读

Dupont E, Sansal I, Toru D; et al. [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]. C. R. Seances Soc. Biol. Fil. 1997, 191 (1): 95–104. PMID 9181131.
Stevens C, La Thangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control.. DNA Repair (Amst.). 2005, 3 (8-9): 1071–9. PMID 15279795. doi:10.1016/j.dnarep.2004.03.034.
Zhang Z, Wang H, Li M; et al. Novel MDM2 p53-independent functions identified through RNA silencing technologies.. Ann. N. Y. Acad. Sci. 2006, 1058 (1): 205–14. PMID 16394138. doi:10.1196/annals.1359.030.
Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G. PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells. Mol. Carcinog. July 2009, 48 (12): 1149–58. PMID 19603422. doi:10.1002/mc.20569.

外部がいぶ链接

E2F1引用いんよう了りょう美国びくに国家こっか医学いがく图书馆提供ていきょう的てき資料しりょう，这些資料しりょう属ぞく于公共こうきょう领域。

[pmid8964493-1] Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. Structure and partial genomic sequence of the human E2F1 gene. Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9.

[2] Entrez Gene: E2F1 E2F transcription factor 1. （原始げんし内容ないよう存そん档于2019-10-16）.

[LiNyman2011-3] Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190.

[pmid14638867-4] Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation. Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867.

[pmid8230483-5] 5.0 ^5.1 Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233 . PMID 8230483.

[pmid11470869-6] Nicolas, E; Ait-Si-Ali S, Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res. (England). August 2001, 29 (15): 3131–6. PMC 55834 . PMID 11470869. doi:10.1093/nar/29.15.3131.

[pmid12397079-7] Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J. Biol. Chem. (United States). December 2002, 277 (52): 50860–6. ISSN 0021-9258. PMID 12397079. doi:10.1074/jbc.M203839200.

[pmid8896460-8] 8.0 ^8.1 Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P. Inhibition of E2F-mediated transcription by p202. EMBO J. (ENGLAND). October 1996, 15 (20): 5668–78. ISSN 0261-4189. PMC 452311 . PMID 8896460.

[pmid10869426-9] Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). July 2000, 97 (14): 7738–43. ISSN 0027-8424. PMC 16614 . PMID 10869426. doi:10.1073/pnas.130198397.

[pmid7739537-10] 10.0 ^10.1 Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. (UNITED STATES). May 1995, 15 (5): 2536–46. ISSN 0270-7306. PMC 230484 . PMID 7739537.

[pmid9422723-11] 11.0 ^11.1 Taniura, H; Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J. Biol. Chem. (UNITED STATES). January 1998, 273 (2): 720–8. ISSN 0021-9258. PMID 9422723. doi:10.1074/jbc.273.2.720.

[pmid10428966-12] Vandel, L; Kouzarides T. Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. EMBO J. (ENGLAND). August 1999, 18 (15): 4280–91. ISSN 0261-4189. PMC 1171504 . PMID 10428966. doi:10.1093/emboj/18.15.4280.

[pmid10559858-13] 13.0 ^13.1 Marti, A; Wirbelauer C, Scheffner M, Krek W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. (ENGLAND). May 1999, 1 (1): 14–9. ISSN 1465-7392. PMID 10559858. doi:10.1038/8984.

[pmid10597240-14] Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011.

[pmid11042687-15] Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843.

[pmid10547281-16] 16.0 ^16.1 ^16.2 ^16.3 Rotheneder, H; Geymayer S, Haidweger E. Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213.

[pmid8657142-17] Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153 . PMID 8657142.

[pmid8657141-18] Karlseder, J; Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152 . PMID 8657141.

[pmid9780002-19] 19.0 ^19.1 Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163.

[pmid12697828-20] Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207 . PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003.

[pmid14576433-21] Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. The BRCT domain is a phospho-protein binding domain. Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753.

[pmid10022926-22] Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032 . PMID 10022926.

[pmid7969176-23] Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381 . PMID 7969176.

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