FOXP3

FOXP3
已やめ知的ちてき結構けっこう
PDB	直系ちょっけい同どう源みなもと搜索そうさく: PDBe RCSB
PDBID列れつ表ひょう
	3QRF、4WK8
識別しきべつ號ごう
别名	FOXP3；, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
外部がいぶID	OMIM：300292 MGI：1891436 HomoloGene：8516 GeneCards：FOXP3
相關そうかん疾病しっぺい
	IPEX症候群しょうこうぐん
基もと因いん位置いち（人ひと类）
染色せんしょく体たい	X染色せんしょく體たい
终止	49,270,477 bp
基もと因いん位置いち（小しょう鼠ねずみ）
染色せんしょく体たい	小しょう鼠ねずみX染色せんしょく体たい
终止	7,461,484 bp
RNA表ひょう达模も式しき
	; ;
	查阅更さら多た表ひょう达数据すえ
基もと因いん本體ほんたい
分子ぶんし功こう能のう	• sequence-specific DNA binding; • NF-kappaB binding; • transcription corepressor activity; • nucleic acid binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • 血ち浆蛋白しろ结合; • histone deacetylase binding; • DNA结合转录因子いんし活性かっせい; • NFAT protein binding; • histone acetyltransferase binding; • 金屬きんぞく離はなれ子こ結合けつごう; • DNA结合; • protein homodimerization activity; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II cis-regulatory region sequence-specific DNA binding;
細胞さいぼう組ぐみ分ぶん	• 细胞核かく; • 胞內; • 細胞さいぼう質しつ; • 核かく质; • 大分おおいた子こ复合体がったい;
生物せいぶつ學がく過程かてい	• negative regulation of cell population proliferation; • negative regulation of NF-kappaB transcription factor activity; • B cell homeostasis; • regulation of isotype switching to IgG isotypes; • myeloid cell homeostasis; • negative regulation of inflammatory response; • positive regulation of interleukin-4 production; • regulation of immunoglobulin production; • regulation of transcription by RNA polymerase II; • regulation of T cell anergy; • negative regulation of interleukin-6 production; • tolerance induction to self antigen; • regulation of transcription, DNA-templated; • negative regulation of DNA-binding transcription factor activity; • positive regulation of T cell tolerance induction; • negative regulation of immune response; • negative regulation of interferon-gamma production; • tolerance induction; • regulatory T cell differentiation; • positive regulation of transcription, DNA-templated; • negative regulation of interleukin-2 production; • positive regulation of histone acetylation; • negative regulation of interleukin-5 production; • negative regulation of chronic inflammatory response; • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; • positive regulation of transcription by RNA polymerase II; • negative regulation of activated T cell proliferation; • positive regulation of gene expression; • negative regulation of interleukin-4 production; • negative regulation of interleukin-10 production; • 腫しゅ瘤こぶ壞死えし因子いんし產さん生せい的てき負まけ調ちょう控ひかえ; • T cell homeostasis; • negative regulation of CREB transcription factor activity; • negative regulation of T-helper 17 cell differentiation; • T细胞活かつ化か; • positive regulation of immature T cell proliferation in thymus; • positive regulation of regulatory T cell differentiation; • negative regulation of transcription by RNA polymerase II; • positive regulation of peripheral T cell tolerance induction; • positive regulation of transforming growth factor beta1 production; • negative regulation of transcription, DNA-templated; • negative regulation of lymphocyte proliferation; • negative regulation of histone acetylation; • negative regulation of interleukin-17 production; • response to virus; • negative regulation of histone deacetylation; • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; • negative regulation of T cell proliferation; • 染色せんしょく体重たいじゅう建けん; • cytokine production; • negative regulation of T cell cytokine production; • negative regulation of isotype switching to IgE isotypes; • T cell receptor signaling pathway; • positive regulation of T cell anergy; • transcription, DNA-templated; • T cell mediated immunity; • negative regulation of gene expression; • anatomical structure morphogenesis; • regulation of Wnt signaling pathway; • regulation of regulatory T cell differentiation;
	Sources:Amigo / QuickGO
直系ちょっけい同どう源みなもと
	50943
	20371
	ENSG00000049768
	ENSMUSG00000039521
	Q9BZS1
	Q99JB6
	NM_001114377; NM_014009
	NM_001199347; NM_001199348; NM_054039
	NP_001107849; NP_054728
	NP_001186276; NP_001186277; NP_473380
	維基數すう據よりどころ
檢視けんし/編輯へんしゅう人類じんるい	檢視けんし/編輯へんしゅう小しょう鼠ねずみ

FOXP3（Forkhead box protein P3）基もと因いん，即そく叉また头框P3基もと因いん，也称为scurfin蛋白たんぱく，位い于X染色せんしょく体たい，属ぞく于FOX蛋白たんぱく家族かぞく，是ぜ一いち种与免疫めんえき系けい统响应有ゆう关的转录因子いんし^[6]。

参考さんこう文献ぶんけん

^ 與あずかFOXP3相關そうかん的てき疾病しっぺい；在ざい維基數すう據よりどころ上じょう查看/編輯へんしゅう參考さんこう.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.

外部がいぶ链接

[1] 與あずかFOXP3相關そうかん的てき疾病しっぺい；在ざい維基數すう據よりどころ上じょう查看/編輯へんしゅう參考さんこう.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Brunkow_2001-6] Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.

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