VDAC2
VDAC2（voltage dependent anion channel 2）は、ヒトでは10
構造
[ヒトのVDACの3つのアイソフォームは、
機能
[VDAC2はミトコンドリアポリンファミリーに
さらに、VDACはミトコンドリア
VDACは
臨床 的 意義
[VDAC2は、ミトコンドリア
VDAC2
また、VDAC2は
VDAC2はIBDウイルスに
相互 作用
[VDAC2は
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000165637 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021771 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms”. Genomics 20 (1): 62–7. (Mar 1994). doi:10.1006/geno.1994.1127. PMID 7517385.
- ^ “Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered”. Biochemical and Biophysical Research Communications 255 (3): 707–10. (Feb 1999). doi:10.1006/bbrc.1998.0136. PMID 10049775.
- ^ “Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning”. Proceedings of the National Academy of Sciences of the United States of America 95 (14): 8175–80. (Jul 1998). doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
- ^ “Isolation of a novel human voltage-dependent anion channel gene”. European Journal of Human Genetics 6 (4): 337–40. (1998). doi:10.1038/sj.ejhg.5200198. PMID 9781040.
- ^ a b “Charged residues distribution modulates selectivity of the open state of human isoforms of the voltage dependent anion-selective channel”. PLOS ONE 9 (8): e103879. (2014). doi:10.1371/journal.pone.0103879. PMC 4146382. PMID 25084457.
- ^ a b c d e “Voltage-dependent anion channel 2 modulates resting Ca²+ sparks, but not action potential-induced Ca²+ signaling in cardiac myocytes”. Cell Calcium 49 (2): 136–43. (Feb 2011). doi:10.1016/j.ceca.2010.12.004. PMID 21241999.
- ^ a b c d e f g “Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production”. American Journal of Respiratory Cell and Molecular Biology 47 (5): 669–78. (Nov 2012). doi:10.1165/rcmb.2011-0436OC. PMC 3547107. PMID 22842492.
- ^ “VDAC2 inhibits BAK activation and mitochondrial apoptosis”. Science 301 (5632): 513–7. (Jul 2003). doi:10.1126/science.1083995. PMID 12881569.
- ^ a b c d e “Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5”. Journal of Virology 86 (3): 1328–38. (Feb 2012). doi:10.1128/JVI.06104-11. PMC 3264341. PMID 22114330.
- ^ “Voltage-dependent anion-selective channel (VDAC) in the plasma membrane”. FEBS Letters 584 (9): 1793–9. (May 2010). doi:10.1016/j.febslet.2010.02.049. PMID 20184885.
- ^ a b “Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway”. Molecular and Cellular Biology 24 (9): 3918–27. (May 2004). doi:10.1128/mcb.24.9.3918-3927.2004. PMC 387743. PMID 15082785.
- ^ a b “Characterization of human VDAC isoforms: a peculiar function for VDAC3?”. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (6–7): 1268–75. (2010). doi:10.1016/j.bbabio.2010.01.031. PMID 20138821.
- ^ “Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell”. FEBS Letters 584 (13): 2837–44. (Jul 2010). doi:10.1016/j.febslet.2010.04.066. PMID 20434446.
- ^ “VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes”. Cell Cycle 11 (19): 3666–78. (Oct 2012). doi:10.4161/cc.21927. PMC 3478317. PMID 22935710.
- ^ “VDAC3 and Mps1 negatively regulate ciliogenesis”. Cell Cycle 12 (5): 849–58. (Mar 2013). doi:10.4161/cc.23824. PMC 3610733. PMID 23388454.
- ^ “The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction”. PLOS ONE 6 (2): e16985. (9 February 2011). doi:10.1371/journal.pone.0016985. PMC 3036732. PMID 21347391.
- ^ “Cell death: critical control points”. Cell 116 (2): 205–19. (Jan 2004). doi:10.1016/S0092-8674(04)00046-7. PMID 14744432.
- ^ “Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics”. British Journal of Cancer 26 (4): 239–57. (Aug 1972). doi:10.1038/bjc.1972.33. PMC 2008650. PMID 4561027.
- ^ “Past and present course of cardioprotection against ischemia-reperfusion injury”. Journal of Applied Physiology 103 (6): 2129–36. (Dec 2007). doi:10.1152/japplphysiol.00383.2007. PMID 17673563.
- ^ “Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy”. The Journal of Biological Chemistry 287 (48): 40652–60. (Nov 2012). doi:10.1074/jbc.M112.419721. PMC 3504778. PMID 23060438.
関連 文献
[- “Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel”. The Journal of Biological Chemistry 268 (3): 1835–41. (Jan 1993). doi:10.1016/S0021-9258(18)53930-2. PMID 8420959.
- “VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation”. Molecular and Cellular Biochemistry 311 (1–2): 225–31. (Apr 2008). doi:10.1007/s11010-008-9712-x. PMID 18278581.
- “Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications”. Journal of Structural Biology 121 (2): 207–18. (1998). doi:10.1006/jsbi.1997.3954. PMID 9615439.
- “The layered structure of human mitochondrial DNA nucleoids”. The Journal of Biological Chemistry 283 (6): 3665–75. (Feb 2008). doi:10.1074/jbc.M708444200. PMID 18063578.
- “Bax-dependent regulation of Bak by voltage-dependent anion channel 2”. The Journal of Biological Chemistry 280 (19): 19051–61. (May 2005). doi:10.1074/jbc.M501391200. PMID 15757910.
- “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. (Nov 2006). doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- “Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome”. Electrophoresis 22 (1): 172–9. (Jan 2001). doi:10.1002/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P. PMID 11197169.
- “Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry”. Journal of Proteome Research 4 (3): 931–40. (2005). doi:10.1021/pr050024a. PMID 15952740.
- “A mitochondrial porin cDNA predicts the existence of multiple human porins”. The Journal of Biological Chemistry 268 (16): 12143–9. (Jun 1993). doi:10.1016/S0021-9258(19)50319-2. PMID 7685033.
- “Subcellular localization of human voltage-dependent anion channel isoforms”. The Journal of Biological Chemistry 270 (23): 13998–4006. (Jun 1995). doi:10.1074/jbc.270.23.13998. PMID 7539795.
- “Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum”. The Journal of Biological Chemistry 279 (15): 15281–8. (Apr 2004). doi:10.1074/jbc.M313433200. PMID 14739283.
- “Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis”. Mammalian Genome 10 (10): 1041–2. (Oct 1999). doi:10.1007/s003359901158. PMID 10501981.
- “Nucleolar proteome dynamics”. Nature 433 (7021): 77–83. (Jan 2005). doi:10.1038/nature03207. PMID 15635413.
- “Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods”. Journal of the American Society for Mass Spectrometry 15 (4): 558–67. (Apr 2004). doi:10.1016/j.jasms.2003.12.006. PMID 15047060.
- “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology 3 (1): 89. (2007). doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
関連 項目
[外部 リンク
[- VDAC2 protein, human - MeSH・アメリカ
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