SECIS元もと件けん

SECIS元もと件けん
	一いち個こSECIS元もと件けん可能かのう的てき次つぎ級きゅう結構けっこう，鹼基標示ひょうじ為ため依よ循IUPAC規則きそく
识别符ふ
代だい号ごう	SECIS_1
Alt.代だい号ごう	SECIS
Rfam	RF00031
	其他数すう据すえ
RNA类型	順じゅん式しき作用さよう元もと件けん

SECIS元もと件けん全ぜん稱しょう為ため硒半胱氨酸さん插入そうにゅう序列じょれつ（SElenoCysteine Insertion Sequence），是ぜ生物せいぶつmRNA中ちゅう一いち個こ長ちょう約やく60nt的てきRNA元もと件けん，次つぎ級きゅう結構けっこう為一ためいち莖くき環たまき^[1] ，此元件けん會かい使し核かく糖とう體からだ轉てん譯やく時どき不ふ將しょうUGA當とう作さく終止しゅうし密みつ碼子，而將其作為さくい編へん碼特殊とくしゅ胺基酸さん硒半胱氨酸さん的てき密みつ碼子，因いん此為編へん碼硒蛋白しろ的てきmRNA所しょ需。三さん域いき生物せいぶつ皆みな有ゆうSECIS元もと件けん^[2]^[3]^[4]^[5]，雖皆為ため莖くき環たまき結構けっこう，但ただし彼此ひし序列じょれつ差異さい很大（不ふ過か洛らく基もと古こ菌きん（英えい语：Lokiarchaeota）的てきSECIS元もと件けん序列じょれつ和わ真ま核かく生物せいぶつ的てき較為接近せっきん）^[6]，細菌さいきん的てきSECIS元もと件けん通常つうじょう緊跟在ざいUGA密みつ碼子之これ後ご，真ま核かく生物せいぶつ與あずか古こ菌きん的てきSECIS元もと件けん則そく位い於mRNA的てき3'非ひ轉てん譯やく區く，可か使つかいmRNA中ちゅう多た於一いち個こUGA密みつ碼子編へん碼硒半はん胱氨酸さん，另外已やめ知ち甲きのえ烷球菌きん屬ぞく的てき一種古菌具有位於5'非ひ轉てん譯やく區く的てきSECIS元もと件けん^[7]^[8]。真ま核かく生物せいぶつ的てきSECIS元もと件けん通常つうじょう有ゆう特殊とくしゅ的てきA：G鹼基配はい對たい，可能かのう對たい其功能のう相當そうとう重要じゅうよう^[9]。SECIS元もと件けん結合けつごう蛋白たんぱく2（SECIS-binding protein 2，簡稱SBP2）可か與あずかSECIS元もと件けん結合けつごう以促進そくしんUGA密みつ碼子編へん碼硒半はん胱氨酸さん^[10]，並なみ可か避免mRNA被ひ無む義介ぎすけ導しるべ的てきmRNA降くだ解かい（NMD）途と徑みち降くだ解かい移うつり除じょ^[11]。

目前もくぜん已やめ有ゆう數すう個こ生なま物資ぶっし訊學軟體可用かよう於尋找基因いん組ぐみ中ちゅう的てきSECIS元もと件けん，有ゆう助じょ於尋找新的てき硒蛋白しろ^[12]。

參考さんこう文獻ぶんけん

^ Walczak R, Westhof E, Carbon P, Krol A. A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs. RNA. April 1996, 2 (4): 367–379. PMC 1369379 . PMID 8634917.
^ Mix H, Lobanov AV, Gladyshev VN. SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Research. 2007, 35 (2): 414–423. PMC 1802603 . PMID 17169995. doi:10.1093/nar/gkl1060.
^ Cassago A, Rodrigues EM, Prieto EL, Gaston KW, Alfonzo JD, Iribar MP, Berry MJ, Cruz AK, Thiemann OH. Identification of Leishmania selenoproteins and SECIS element. Molecular and Biochemical Parasitology. October 2006, 149 (2): 128–134. PMID 16766053. doi:10.1016/j.molbiopara.2006.05.002.
^ Mourier T, Pain A, Barrell B, Griffiths-Jones S. A selenocysteine tRNA and SECIS element in Plasmodium falciparum. RNA. February 2005, 11 (2): 119–122. PMC 1370700 . PMID 15659354. doi:10.1261/rna.7185605.
^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science. May 2003, 300 (5624): 1439–1443 [2021-05-23]. PMID 12775843. doi:10.1126/science.1083516. （原始げんし内容ないよう存そん档于2018-07-23）.
^ Mariotti, Marco; Lobanov, Alexei V.; Manta, Bruno; Santesmasses, Didac; Bofill, Andreu; Guigó, Roderic; Gabaldón, Toni; Gladyshev, Vadim N. Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Molecular Biology and Evolution. 2016, 33 (9): 2441–2453. ISSN 0737-4038. doi:10.1093/molbev/msw122.
^ Wilting R, Schorling S, Persson BC, Böck A. Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion. Journal of Molecular Biology. March 1997, 266 (4): 637–641. PMID 9102456. doi:10.1006/jmbi.1996.0812.
^ Rother M, Resch A, Wilting R, Böck A. Selenoprotein synthesis in archaea. BioFactors. 2001, 14 (1–4): 75–83. PMID 11568443. doi:10.1002/biof.5520140111.
^ JULIA E. FLETCHER, PAUL R. COPELAND, DONNA M. DRISCOLL, ALAIN KROL. The selenocysteine incorporation machinery: Interactions between the SECIS RNA and the SECIS-binding protein SBP2 (PDF). RNA. 2001, 7: 1442-1453 [2021-05-23]. （原始げんし内容ないよう存そん档 (PDF)于2021-05-23）.
^ Donovan J, Copeland PR. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.. PLoS One. 2012, 7 (4): e35581. PMC 3328465 . PMID 22530054. doi:10.1371/journal.pone.0035581.
^ Chellan B, Zhao L, Landeche M, Carmean CM, Dumitrescu AM, Sargis RM. Selenocysteine insertion sequence binding protein 2 (Sbp2) in the sex-specific regulation of selenoprotein gene expression in mouse pancreatic islets.. Sci Rep. 2020, 10 (1): 18568. PMC 7596060 . PMID 33122797. doi:10.1038/s41598-020-75595-4.
^ Lambert A, Lescure A, Gautheret D. A survey of metazoan selenocysteine insertion sequences. Biochimie. September 2002, 84 (9): 953–959. PMID 12458087. doi:10.1016/S0300-9084(02)01441-4.

[1] Walczak R, Westhof E, Carbon P, Krol A. A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs. RNA. April 1996, 2 (4): 367–379. PMC 1369379 . PMID 8634917.

[pmid17169995-2] Mix H, Lobanov AV, Gladyshev VN. SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Research. 2007, 35 (2): 414–423. PMC 1802603 . PMID 17169995. doi:10.1093/nar/gkl1060.

[pmid16766053-3] Cassago A, Rodrigues EM, Prieto EL, Gaston KW, Alfonzo JD, Iribar MP, Berry MJ, Cruz AK, Thiemann OH. Identification of Leishmania selenoproteins and SECIS element. Molecular and Biochemical Parasitology. October 2006, 149 (2): 128–134. PMID 16766053. doi:10.1016/j.molbiopara.2006.05.002.

[pmid15659354-4] Mourier T, Pain A, Barrell B, Griffiths-Jones S. A selenocysteine tRNA and SECIS element in Plasmodium falciparum. RNA. February 2005, 11 (2): 119–122. PMC 1370700 . PMID 15659354. doi:10.1261/rna.7185605.

[pmid=12775843-5] Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science. May 2003, 300 (5624): 1439–1443 [2021-05-23]. PMID 12775843. doi:10.1126/science.1083516. （原始げんし内容ないよう存そん档于2018-07-23）.

[MariottiLobanov2016-6] Mariotti, Marco; Lobanov, Alexei V.; Manta, Bruno; Santesmasses, Didac; Bofill, Andreu; Guigó, Roderic; Gabaldón, Toni; Gladyshev, Vadim N. Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Molecular Biology and Evolution. 2016, 33 (9): 2441–2453. ISSN 0737-4038. doi:10.1093/molbev/msw122.

[7] Wilting R, Schorling S, Persson BC, Böck A. Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion. Journal of Molecular Biology. March 1997, 266 (4): 637–641. PMID 9102456. doi:10.1006/jmbi.1996.0812.

[8] Rother M, Resch A, Wilting R, Böck A. Selenoprotein synthesis in archaea. BioFactors. 2001, 14 (1–4): 75–83. PMID 11568443. doi:10.1002/biof.5520140111.

[9] JULIA E. FLETCHER, PAUL R. COPELAND, DONNA M. DRISCOLL, ALAIN KROL. The selenocysteine incorporation machinery: Interactions between the SECIS RNA and the SECIS-binding protein SBP2 (PDF). RNA. 2001, 7: 1442-1453 [2021-05-23]. （原始げんし内容ないよう存そん档 (PDF)于2021-05-23）.

[pmid22530054-10] Donovan J, Copeland PR. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.. PLoS One. 2012, 7 (4): e35581. PMC 3328465 . PMID 22530054. doi:10.1371/journal.pone.0035581.

[pmid33122797-11] Chellan B, Zhao L, Landeche M, Carmean CM, Dumitrescu AM, Sargis RM. Selenocysteine insertion sequence binding protein 2 (Sbp2) in the sex-specific regulation of selenoprotein gene expression in mouse pancreatic islets.. Sci Rep. 2020, 10 (1): 18568. PMC 7596060 . PMID 33122797. doi:10.1038/s41598-020-75595-4.

[pmid=12458087-12] Lambert A, Lescure A, Gautheret D. A survey of metazoan selenocysteine insertion sequences. Biochimie. September 2002, 84 (9): 953–959. PMID 12458087. doi:10.1016/S0300-9084(02)01441-4.

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