CXCL10

CXCL10
已やめ知的ちてき結構けっこう
PDB	直系ちょっけい同どう源みなもと搜さがせ尋ひろ: PDBe RCSB
PDBID列れつ表ひょう
	1O80、1LV9、1O7Y、1O7Z
識別しきべつ號ごう
別名べつめい	CXCL10；, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部がいぶID	OMIM：147310 MGI：1352450 HomoloGene：1203 GeneCards：CXCL10
基もと因いん位置いち（人類じんるい）
染色せんしょく體たい	4號ごう染色せんしょく體たい
終止しゅうし	76,023,497 bp
基もと因いん位置いち（小しょう鼠ねずみ）
染色せんしょく體たい	小しょう鼠ねずみ5號ごう染色せんしょく體たい
終止しゅうし	92,496,748 bp
RNA表現ひょうげん模も式しき
	查閱更さら多た表現ひょうげん資料しりょう
基もと因いん本體ほんたい
分子ぶんし功こう能のう	• 細胞さいぼう因子いんし活性かっせい; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • 血漿けっしょう蛋白たんぱく結合けつごう; • cAMP-dependent protein kinase regulator activity; • signaling receptor binding; • chemoattractant activity;
細胞さいぼう組ぐみ分ぶん	• 細胞さいぼう外がい區域くいき; • external side of plasma membrane; • 細胞さいぼう外がい空間くうかん; • 胞內;
生物せいぶつ學がく過程かてい	• regulation of endothelial tube morphogenesis; • negative regulation of myoblast differentiation; • cellular response to heat; • response to vitamin D; • positive regulation of cell migration; • T cell chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • response to virus; • muscle organ development; • positive regulation of monocyte chemotaxis; • positive regulation of release of sequestered calcium ion into cytosol; • endothelial cell activation; • positive regulation of cAMP-mediated signaling; • regulation of T cell chemotaxis; • blood circulation; • 趨化性せい; • positive regulation of leukocyte chemotaxis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • negative regulation of myoblast fusion; • defense response to virus; • regulation of cell population proliferation; • 免疫めんえき反應はんのう; • positive regulation of cell population proliferation; • response to auditory stimulus; • negative regulation of angiogenesis; • response to cold; • cellular response to lipopolysaccharide; • response to gamma radiation; • positive regulation of T cell migration; • 訊息傳でん遞; • positive regulation of transcription by RNA polymerase II; • regulation of protein kinase activity; • defense response; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • response to bacterium; • neutrophil chemotaxis; • leukocyte chemotaxis; • positive chemotaxis; • regulation of apoptotic process;
	Sources:Amigo / QuickGO
直系ちょっけい同どう源みなもと
	3627
	15945
	ENSG00000169245
	ENSMUSG00000034855
	P02778
	P17515
	NM_001565
	NM_021274
	NP_001556
	NP_067249
	維基資料しりょう
檢視けんし/編輯へんしゅう人類じんるい	檢視けんし/編輯へんしゅう小しょう鼠ねずみ

CXCL10（英語えいご：C-X-C motif chemokine 10）是ぜ一いち小しょう分子ぶんし的てき細胞さいぼう因子いんし屬ぞく於CXC趨化因子いんし家族かぞく^[5]，又また被ひ稱しょう作さく「干ひ擾素伽とぎ瑪誘導ゆうどう的てき10千せん道どう爾しか頓ひたぶる蛋白たんぱく」（10 kDa interferon-gamma-induced protein，IP-10）^[6] 。干ひ擾素伽とぎ瑪可か以在多種たしゅ細胞さいぼう（如巨きょ噬細胞さいぼう^[7] ，單たん核かく球だま^[7] ，內皮細胞さいぼう^[8]和わ纖維せんい母はは細胞さいぼう）中ちゅう誘導ゆうどうCXCL10的てき表現ひょうげん。CXCL10的てき功こう能のう包括ほうかつ對たいT細胞さいぼう和かず單たん核かく球だま的てき細胞さいぼう趨化作用さよう^[9]^[10]，促進そくしんT細胞さいぼう黏附於內皮がわ細胞さいぼう^[8]，抗こう腫しゅ瘤こぶ^[11]，及血管けっかん新生しんせい^[8]。人類じんるい的てきCXCL10基き因いん與あずかCXCL9，CXCL11的てき基もと因いん相しょう鄰聚集しゅう在ざい第だい四よん染色せんしょく體たい上じょう。CXCL10, CXCL9和わCXCL11結合けつごう趨化因子いんし受體 CXCR3而起其細胞趨化か作用さよう^[9]^[10] 。

參まいり見み

參考さんこう文獻ぶんけん

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
^ ^7.0 ^7.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
^ ^8.0 ^8.1 ^8.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
^ ^9.0 ^9.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
^ ^10.0 ^10.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部がいぶ連結れんけつ

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（頁ぺーじ面めん存そん檔備份，存そん於網あみ際ぎわ網もう路ろ檔案館かん）

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.

[6] Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.

[nor-7] 7.0 ^7.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.

[ang-8] 8.0 ^8.1 ^8.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.

[chemo-9] 9.0 ^9.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[fun-10] 10.0 ^10.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

[11] Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]