美よし西林にしばやし

**美よし西林にしばやし**
臨床りんしょう資料しりょう
商品しょうひん名めい（英えい语：Drug nomenclature）	Coactin, Leo, Selexid, Selexidin
AHFS/Drugs.com	国くに际药品ひん名称めいしょう
懷ふところ孕分級きゅう	無風むふう險けわし;
给药途と径みち	靜脈じょうみゃく注射ちゅうしゃ、肌はだ肉にく注射ちゅうしゃ
ATC碼	J01CA11 (WHO) ;
法律ほうりつ規範きはん狀態じょうたい
法律ほうりつ規範きはん	澳：限きり医い生せい处方（S4）; 英えい：处方药（℞-only） (POM); 处方药（℞-only）;
藥物やくぶつ動力どうりょく學がく數かず據よりどころ
生物せいぶつ利用りよう度ど	可か忽ゆるがせ略りゃく
血漿けっしょう蛋白たんぱく結合けつごう率りつ	5-10%
药物代だい谢	肝臟かんぞう
生物せいぶつ半はん衰おとろえ期き	1-3小しょう時じ
排泄はいせつ途と徑みち	腎じん、膽きも
识别信しん息いき
	IUPAC命名めいめい法ほう (2S,5R,6R)-6-[(E/Z)-(Azepan-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; ;
CAS号ごう	32887-01-7
PubChem CID	36273;
DrugBank	DB01163 ;
ChemSpider	33357 ;
UNII	V10579P3QZ;
KEGG	D02888 ;
ChEMBL	ChEMBL530 ;
CompTox Dashboard（英えい语：CompTox Chemicals Dashboard） (EPA)	DTXSID3022584 ;
ECHA InfoCard	100.046.601
化学かがく信しん息いき
化学かがく式しき	C15H23N3O3S
摩ま尔质量りょう	325.426 g/mol
3D模型もけい（JSmol（英えい语：JSmol））	交互こうご式しき图像;
	SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N=CN3CCCCCC3)C(=O)O)C;

美よし西林にしばやし（INN：Mecillinam；USAN：Amdinocillin）是ぜ一いち種しゅ广谱半はん合成ごうせい青あお霉素^[2]，對たい革かわ兰氏阴性菌きん作用さよう强きょう，也可用よう來らい治療ちりょう傷寒しょうかん和わ副ふく伤寒^[3]^[4]。其口服ふく利用りよう率りつ很差，匹ひき美び西林にしばやし則のり是ぜ針はり對たい此缺陷けっかん開發かいはつ出來でき的てき。^[5]

這種藥物やくぶつ是ぜ荷に蘭らん製藥せいやく公司こうし“Leo Pharmaceutical Products”（今いま利り奥おく制せい药）研とぎ發はつ出來でき的てき，最初さいしょ代だい號ごう為ためFL 1060，1972年ねん面めん世よ。^[6]^[7]

參考さんこう文獻ぶんけん[编辑]

^ Nicolle LE. Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35.
^ Neu HC. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x.
^ Clarke PD, Geddes AM, McGhie D, Wall JC. Mecillinam: a new antibiotic for enteric fever. Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648 . PMID 820402. doi:10.1136/bmj.2.6026.14.
^ Geddes AM, Clarke PD. The treatment of enteric fever with mecillinam. J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101.
^ Pham P, Bartlett JG. Amdinocillin (Mecillinam). Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. （原始げんし内容ないよう存そん档于2009-02-04）. Retrieved on August 31, 2008. Freely available with registration.
^ Lund F, Tybring L. 6βべーた-amidinopenicillanic acids—a new group of antibiotics. Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0.
^ Tybring L, Melchior NH. Mecillinam (FL 1060), a 6βべーた-Amidinopenicillanic Acid Derivative: Bactericidal Action and Synergy In Vitro. Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305 . PMID 170856. doi:10.1128/aac.8.3.271. （原始げんし内容ないよう存そん档于2019-12-14）.

[Nicolle-1] Nicolle LE. Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35.

[Neu-2] Neu HC. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x.

[3] Clarke PD, Geddes AM, McGhie D, Wall JC. Mecillinam: a new antibiotic for enteric fever. Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648 . PMID 820402. doi:10.1136/bmj.2.6026.14.

[4] Geddes AM, Clarke PD. The treatment of enteric fever with mecillinam. J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101.

[POC-IT-5] Pham P, Bartlett JG. Amdinocillin (Mecillinam). Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. （原始げんし内容ないよう存そん档于2009-02-04）. Retrieved on August 31, 2008. Freely available with registration.

[6] Lund F, Tybring L. 6βべーた-amidinopenicillanic acids—a new group of antibiotics. Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0.

[7] Tybring L, Melchior NH. Mecillinam (FL 1060), a 6βべーた-Amidinopenicillanic Acid Derivative: Bactericidal Action and Synergy In Vitro. Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305 . PMID 170856. doi:10.1128/aac.8.3.271. （原始げんし内容ないよう存そん档于2019-12-14）.

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