亚胺培 南
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Primaxin | |
AHFS/Drugs.com | |
MedlinePlus | a686013 |
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给药 | IM, IV |
ATC碼 | |
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20% | |
药物 | 肾 |
38 minutes (children), 60 minutes (adults) | |
Urine (70%) | |
识别 | |
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CAS | 64221-86-9 ![]() |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.058.831 |
C12H17N3O4S | |
299.347 g/mol | |
3D | |
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亚胺
历史
[编辑]临床应用
[编辑]临床
复方制 剂
[编辑]单独给药时,亚胺
不良 反 应
[编辑]作用 机 理
[编辑]亚胺
抗菌 谱
[编辑]亚胺
参考 文献
[编辑]- ^
美國 專 利 第 4,194,047号 - ^ Clissold, SP; Todd, PA; Campoli-Richards, DM. Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.. Drugs. Mar 1987, 33 (3): 183–241. PMID 3552595. doi:10.2165/00003495-198733030-00001.
- ^ Vardakas, KZ; Tansarli, GS; Rafailidis, PI; Falagas, ME. Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to Enterobacteriaceae producing extended-spectrum
β -lactamases: a systematic review and meta-analysis.. The Journal of Antimicrobial Chemotherapy. Dec 2012, 67 (12): 2793–803. PMID 22915465. doi:10.1093/jac/dks301. - ^ Kahan, FM; Kropp, H; Sundelof, JG; Birnbaum, J. Thienamycin: development of imipenen-cilastatin.. The Journal of Antimicrobial Chemotherapy. Dec 1983,. 12 Suppl D: 1–35. PMID 6365872. doi:10.1093/jac/12.suppl_d.1.
- ^ Fischer, Janos; Ganellin, C. Robin. Analogue-based Drug Discovery. John Wiley & Sons. 2006: 497 [2019-09-06]. ISBN 9783527607495. (
原始 内容 存 档于2020-09-17) (英 语). - ^ IMIPENEM/CILASTATIN. livertox.nih.gov. [2019-03-08]. (
原始 内容 存 档于2016-12-13). - ^ Cannon, Joan P.; Lee, Todd A.; Clark, Nina M.; Setlak, Paul; Grim, Shellee A. The risk of seizures among the carbapenems: a meta-analysis. Journal of Antimicrobial Chemotherapy. 2014-08-01, 69 (8): 2043–2055 [2019-09-06]. ISSN 0305-7453. doi:10.1093/jac/dku111. (
原始 内容 存 档于2022-01-21) (英 语). - ^ Kesado, Tadataka; Hashizume, Terutaka; Asahi, Yoshinari. Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics. Antimicrobial Agents and Chemotherapy. 1980, 17 (6): 912–7 [2019-09-06]. PMC 283902
. PMID 6931548. doi:10.1128/aac.17.6.912. (
原始 内容 存 档于2012-07-08). - ^ Imipenem spectrum of bacterial susceptibility and Resistance (PDF). [4 May 2012]. (
原始 内容 (PDF)存 档于2016-03-03).
延 申 阅读
[编辑]- Clissold, SP; Todd, PA; Campoli-Richards, DM. Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1987, 33 (3): 183–241 [2019-09-06]. PMID 3552595. doi:10.2165/00003495-198733030-00001. (
原始 内容 存 档于2011-09-17). - Buckley, MM; Brogden, RN; Barradell, LB; Goa, KL. Imipenem/cilastatin. A reappraisal of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1992, 44 (3): 408–44 [2019-09-06]. PMID 1382937. doi:10.2165/00003495-199244030-00008. (
原始 内容 存 档于2012-04-06).
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